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Awareness of the Tuskegee Syphilis Study and the US Presidential Apology and Their Influence on Minority Participation in Biomedical Research

机译：对塔斯基吉梅毒研究和美国总统道歉的认识及其对少数群体参与生物医学研究的影响

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OBJECTIVES: We compared the influence of awareness of the Tuskegee Syphilis Study and the presidential apology for that study on the willingness of Blacks, non-Hispanic Whites, and Hispanics to participate in biomedical research.METHODS: The Tuskegee Legacy Project Questionnaire was administered to 1133 adults in 4 US cities. This 60-item questionnaire addressed issues related to the recruitment of minorities into biomedical studies.RESULTS: Adjusted multivariate analysis showed that, compared with Whites, Blacks were nearly 4 times as likely to have heard of the Tuskegee Syphilis Study, more than twice as likely to have correctly named Clinton as the president who made the apology, and 2 to 3 times more likely to have been willing to participate in biomedical studies despite having heard about the Tuskegee Syphilis Study (odds ratio [OR]=2.9; 95% confidence interval [CI]=1.4, 6.2) or the presidential apology (OR=2.3; 95% CI=1.4, 3.9).CONCLUSIONS: These marked differences likely reflect the cultural reality in the Black community, which has been accustomed to increased risks in many activities. For Whites, this type of information may have been more shocking and at odds with their expectations and, thus, led to a stronger negative impact.
机译：目的：我们比较了了解塔斯凯吉梅毒研究和总统道歉对黑人，非西班牙裔白人和西班牙裔美国人参加生物医学研究的意愿的影响。方法：塔斯克吉传统项目问卷调查于1133年进行美国4个城市的成年人。这份60项问卷调查了与招募少数族裔人士参加生物医学研究有关的问题。结果：经过调整的多变量分析表明，与白人相比，黑人听说过Tuskegee Syphilis研究的可能性接近四倍，是黑人的两倍。正确地将克林顿任命为做出道歉的主席，并且尽管听说过塔斯基吉梅毒研究，但愿意参加生物医学研究的可能性却增加了2至3倍（赔率[OR] = 2.9；置信区间为95％） [CI] = 1.4，6.2）或总统道歉（OR = 2.3; 95％CI = 1.4，3.9）。结论：这些明显的差异可能反映了黑人社区的文化现实，该现实已习惯于增加许多黑人的风险活动。对于白人来说，这类信息可能更令人震惊，与他们的期望背道而驰，从而导致更大的负面影响。

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